PuraMatrix® has been used in many different clinical and research applications for more than fifteen years. Its versatility is demonstrated through the large body of literature that covers its broad applications.

Bone Cartilage Regeneration

Investigation of different cell types and gel carriers for cell-based intervertebral disc therapy, in vitro and in vivo studies.
J Tissue Eng Regen Med. 2011 Nov 9. doi: 10.1002/term.480. [Epub ahead of print]
Henriksson H, Hagman M, Horn M, Lindahl A, Brisby H.
Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Gothenburg University, Gothenburg, Sweden; Department of Orthopaedics, Sahlgrenska University, Gothenburg University, Gothenburg, Sweden.
Copyright © 2011 John Wiley & Sons, Ltd.

Evaluation of early and late effects into the acute spinal cord injury of an injectable functionalized self-assembling scaffold.
PLoS One. 2011;6(5):e19782. Epub 2011 May 18.
Cigognini D, Satta A, Colleoni B, Silva D, Donegà M, Antonini S, Gelain F.
Biotechnology and Biosciences Department, University of Milano-Bicocca, Milano, Italy.

Bone repair using a hybrid scaffold of self-assembling peptide PuraMatrix and polyetheretherketone cage in rats.
Cell Transplant. 2010;19(6):791-7. Epub 2010 Jun 23.
Nakahara H, Misawa H, Yoshida A, Hayashi T, Tanaka M, Furumatsu T, Tanaka N, Kobayashi N, Ozaki T.
Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

The composition of hydrogels for cartilage tissue engineering can influence glycosaminoglycan profile.
Eur Cell Mater. 2010 Feb 26;19:86-95.
Wang QG, Hughes N, Cartmell SH, Kuiper NJ.
School of Medicine (Keele campus), Institute for Science & Technology in Medicine, University of Keele, Staffordshire, ST5 5BG, UK.

A nanofibrous cell-seeded hydrogel promotes integration in a cartilage gap model.
J Tissue Eng Regen Med. 2010 Jan;4(1):25-9.
Maher SA, Mauck RL, Rackwitz L, Tuan RS
Hospital for Special Surgery, New York, NY 10021, USA.
2009 John Wiley & Sons, Ltd.

Self-assembling peptide nanofiber scaffolds, platelet-rich plasma, and mesenchymal stem cells for injectable bone regeneration with tissue engineering.
J Craniofac Surg. 2009 Sep;20(5):1523-30.
Yoshimi R, Yamada Y, Ito K, Nakamura S, Abe A, Nagasaka T, Okabe K, Kohgo T, Baba S, Ueda M.
Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, Japan.

Mechanics and mechanobiology of mesenchymal stem cell-based engineered cartilage.
J Biomech. 2010 Jan 5;43(1):128-36. Epub 2009 Oct 13.
Huang AH, Farrell MJ, Mauck RL.
University of Pennsylvania
Copyright 2009 Elsevier Ltd. All rights reserved.

Reconstructing Mandibular Defects Using Autologous Tissue-Engineered Tooth and Bone Constructs.
J Oral Maxillofac Surg. 2009 Feb;67(2):335-47.
Abukawa H, Zhang W, Young CS, Asrican R, Vacanti JP, Kaban LB, Troulis MJ, Yelick PC.
Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, MA, USA.

Transplantation of human mesenchymal stems cells into intervertebral discs in a senogeneic porcine model.
Spine (Phila Pa 1976). 2009 Jan 15;34(2):141-8.
Henriksson HB, Svanvik T, Jonsson M, Hagman M, Horn M, Lindahl A, Brisby H.
The Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Self-assembling peptides: from bio-inspired materials to bone regeneration.
J Dent Res. 2008 Jul;87(7):606-16.
Semino CE.
Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Reknitting the injured spinal cord by self-assembling peptide nanofiber scaffold.
Nanomedicine. 2007 Dec;3(4):311-21. Epub 2007 Oct 26.
Guo J, Su H, Zeng Y, Liang YX, Wong WM, Ellis-Behnke RG, So KF, Wu W.
Department of Anatomy, The University of Hong Kong Li Ka Shing Faculty of Medicine, Pokfulam, Hong Kong SAR, China.

Bone Regeneration for Dental Implants Using Tissue-Engineered Bone With Self-Assembling Peptide Nanofiber 3-Dimensional (3D) Scaffolds.
Journal of Oral and Maxillofacial Surgery Volume 65, Issue 9, Supplement, Page 43.e63, September 2007.
Yoshimi, R, Yamada, Y, Ito, K, Okabe, K, Kohgo, T, Baba, S, Ueda, M, Yajima, A
© 2007 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

Effect of different materials on the proliferation and migration of articular chondrocytes.
Osteoarthritis and Cartilage Volume 15, Supplement B, 2007, Pages B119. Abstracts of the 7th World Congress of the International Cartilage Repair Society ICRS 2007. Available online 5 September 2007.
Concaro S, Lonnqvist C, Lindahl A, Gatenholm P, Brittberg M.
Ort, Sahlgrenska University Hospital, G, Sweden; Deparment Of Biopolymer Technology, Chalmers institute of technology, Göteborg, Sweden; University, Gothenburg, Göteborg, Sweden; Biopolymer Technology, Chalmers University of Technology, Göteborg, Sweden, Orthopaedic Department, Cartilage Research Unit, G, Kungsbacka, Sweden
Copyright © 2007 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

Biological designer self-assembling peptide nanofiber scaffolds significantly enhance osteoblast proliferation, differentiation and 3-D migration.
PLoS One. 2007 Feb 7;2(2):e190.
Horii A, Wang X, Gelain F, Zhang S.
Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

Osteogenic differentiation of mouse embryonic stem cells and mouse embryonic fibroblasts in a three-dimensional self-assembling peptide scaffold.
Tissue Eng. 2006 Aug;12(8):2215-27.
Garreta E, Genové E, Borrós S, Semino CE.
Barcelona Bioengineering Center, Institut Químic de Sarrià, Universitat Ramon Llull, Barcelona, Spain.

Cartilage tissue engineering using human auricular chondrocytes embedded in different hydrogel materials.
J Biomed Mater Res A. 2006 Jul;78(1):1-11.
Yamaoka H, Asato H, Ogasawara T, Nishizawa S, Takahashi T, Nakatsuka T, Koshima I, Nakamura K,Kawaguchi H, Chung UI, Takato T, Hoshi K.
Department of Fujisoft ABC Cartilage and Bone Regeneration, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-Ku, Tokyo 113-0033, Japan.
Copyright (c) 2006 Wiley Periodicals, Inc.

Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair.
Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9996-10001. Epub 2002 Jul 15.
Kisiday J, Jin M, Kurz B, Hung H, Semino C, Zhang S, Grodzinsky AJ.
Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139-4307, USA.

PuraMatrix facilitates bone regeneration in bone defects of calvaria in mice.Cell Transplant. 2006;15(10):903-10.
Misawa H, Kobayashi N, Soto-Gutierrez A, Chen Y, Yoshida A, Rivas-Carrillo JD, Navarro-Alvarez N,Tanaka K, Miki A, Takei J, Ueda T, Tanaka M, Endo H, Tanaka N, Ozaki T.
Department of Orthopeadic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.


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