PuraMatrix® has been used in many different clinical and research applications for more than fifteen years. Its versatility is demonstrated through the large body of literature that covers its broad applications.

Drug Delivery

Sustained delivery of VEGF from designer self-assembling peptides improves cardiac function after myocardial infarction.
Biochem Biophys Res Commun. 2012 Jul 20;424(1):105-11. Epub 2012 Jun 22.
Guo HD, Cui GH, Yang JJ, Wang C, Zhu J, Zhang LS, Jiang J, Shao SJ.
Department of Anatomy, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Copyright © 2012 Elsevier Inc. All rights reserved.

Hydrogels for protein delivery in tissue engineering.
J Control Release. 2012 Jul 20;161(2):680-92. Epub 2012 Mar 8.
Censi R, Di Martino P, Vermonden T, Hennink WE.
School of Pharmacy, University of Camerino, via S. Agostino 1, 62032, Camerino (MC), Italy.
Copyright © 2012 Elsevier B.V. All rights reserved.

Controlled release of insulin from self-assembling nanofiber hydrogel, PuraMatrix®: application for the subcutaneous injection in rats.
Eur J Pharm Sci. 2012 Jan 23;45(1-2):1-7. Epub 2011 Oct 28.
Nishimura A, Hayakawa T, Yamamoto Y, Hamori M, Tabata K, Seto K, Shibata N.
Department of Biopharmaceutics, Doshisha Women’s College of Liberal Arts, Kyotanabe, Kyoto 610-0395, Japan.
Copyright © 2011 Elsevier B.V. All rights reserved.

Controlled release of paclitaxel from a self-assembling peptide hydrogel formed in situ and antitumor study in vitro.
Int J Nanomedicine. 2011;6:2143-53. Epub 2011 Sep 27.
Liu J, Zhang L, Yang Z, Zhao X.
West China Hospital Laboratory of Nanomedicine and Institute for Nanobiomedical Technology and Membrane Biology, Sichuan University, Chengdu, China.

The interactions between doxorubicin and amphiphilic and acidic β-sheet peptides towards drug delivery hydrogels.
J Colloid Interface Sci. 2011 Aug 15;360(2):525-31. Epub 2011 Apr 29.
Zarzhitsky S, Rapaport H.
Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
Copyright © 2011 Elsevier Inc. All rights reserved.

Improved preclinical safety assessment using micro-BAL devices: the potential impact on human discovery and drug attrition.
Drug Discov Today. 2011 May;16(9-10):382-97. Epub 2011 Feb 24.
Giri S, Bader A.
Centre for Biotechnology and Biomedicine, Department of Cell Techniques and Applied Stem Cell Biology, University of Leipzig, Deutscher Platz 5, D-04103 Leipzig, Germany.
Copyright © 2011 Elsevier Ltd. All rights reserved.

Slow and sustained release of active cytokines from self-assembling peptide scaffolds.
J Control Release. 2010 Aug 3;145(3):231-9. Epub 2010 May 4.
Gelain F, Unsworth LD, Zhang S.
Center for Nanomedicine and Tissue Engineering, Pad. Mariani A.O. Ospedale Niguarda Ca’ Granda Piazza dell’ospedale maggiore 3, Milan 20162, Italy.
Copyright (c) 2010 Elsevier B.V. All rights reserved.

3D Matrices for Anti-Cancer Drug Testing and Development.
Oncology Issues January/February 2010: 20-25
Gurski LA, Petrelli NJ, Jia X, Farach-Carson MC
University of Delaware

The downmodulation of the foreign body reaction by cytomegalovirus encoded interleukin-10.
Biomaterials. 2009 Feb;30(5):730-5. Epub 2008 Nov 26.
van Putten SM, Wübben M, Hennink WE, van Luyn MJ, Harmsen MC.
Department of Pathology and Medical Biology, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, EA11, 9713 GZ Groningen, The Netherlands.

Self-assembling materials for therapeutic delivery.
Acta Biomaterialia Volume 5, Issue 3, March 2009, Pages 817–831. Available online 10 October 2008.
Branco MC, Schneider JP
Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA; Department of Chemical Engineering, University of Delaware, Newark, DE 19716, USA
Copyright © 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Engineering insulin-like growth factor-1 for local delivery.
Tokunou T, Miller R, Patwari P, Davis ME, Segers VF, Grodzinsky AJ, Lee RT.
FASEB J. 2008 Jun;22(6):1886-93. Epub 2008 Feb 19.
Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Local delivery of protease-resistant stromal cell derived factor-1 for stem cell recruitment after myocardial infarction.
Circulation. 2007 Oct 9;116(15):1683-92. Epub 2007 Sep 17.
Segers VF, Tokunou T, Higgins LJ, MacGillivray C, Gannon J, Lee RT.
Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Mass, USA.

Local delivery of proteins and the use of self-assembling peptides.Drug Discov Today.
2007 Jul;12(13-14):561-8. Epub 2007 Jun 26.
Segers VF, Lee RT
Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA.

Local controlled intramyocardial delivery of platelet-derived growth factor improves postinfarction ventricular function without pulmonary toxicity.
Circulation. 2006 Aug 15;114(7):637-44. Epub 2006 Aug 7.
Hsieh PC, MacGillivray C, Gannon J, Cruz FU, Lee RT.
Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, Mass., USA.

Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction.
Proc Natl Acad Sci U S A. 2006 May 23;103(21):8155-60. Epub 2006 May 12.
Davis ME, Hsieh PC, Takahashi T, Song Q, Zhang S, Kamm RD, Grodzinsky AJ, Anversa P, Lee RT.
Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02139, USA.

Controlled delivery of PDGF-BB for myocardial protection using injectable self-assembling peptide nanofibers.
J Clin Invest. 2006 January 4; 116(1): 237–248.
Published online 2005 December 15. doi:  10.1172/JCI25878
Hsieh PCH, Davis ME, Gannon J, MacGillivray C, Lee RT
Harvard Medical School

Injectable self-assembling peptide nanofibers create intramyocardial microenvironments for endothelial cells.
Circulation. 2005 Feb 1;111(4):442-50.
Davis ME, Motion JP, Narmoneva DA, Takahashi T, Hakuno D, Kamm RD, Zhang S, Lee RT.
Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA.


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